We have tested these seeds and found they are great for pain. We have in our limited tests found people found relieve to major body pain without the side effects of perception pain medicine. Also many people find that the anti inflammatory effects of Akuamma cause them to need less and less to manage their pain. Some find taking them before bed works great where a few find they have odd dreams and are restless at night. So test them on a day you do not have to work the next day if you wish to take before bed.
Dose we recommend is 2 to 6 -00- caps every 4 to 6 hours. Many have found one dose is all they need all day. These same people was needed multiple doses of the current pain treatment they where using before akuamma.
Akuammine, an indole alkaloid, is the most abundant active alkaloid found in the seeds from the tree Picralima nitida, commonly known as Akuamma.
The dried seeds from this plant are used in traditional medicine throughout West Africa, particularly in Ghana as well as in the Ivory Coast and Nigeria. The seeds are crushed or powdered and taken orally, and are mainly used for the treatment of malaria and diarrhoea, and as a painkiller. An enterprising Ghanaian hospital started manufacturing standardised 250mg capsules of the powdered P. nitida seed, and sold them around the country where they became widely accepted as a safe and effective pain relief product. This then led researchers to try and discover the active component of the seeds.
P. nitida seeds contain a mixture of alkaloids producing antipyretic and antiinflammatory effects along with analgesia. Several of these were shown to bind to opioid receptors in vitro, and two compounds, akuammidine and ψ-akuammigine, were found to be potent μ-opioid agonists, although not particularly selective. Surprisingly the main alkaloid from the seeds, akuammine, was found to be an opioid antagonist when tested in vitro and canceled out the effects of the active agonist components.
Given the confirmed activity of the whole seed extract in humans, this makes it likely that akuammine is in fact being metabolised once inside the body to form an active metabolite, in a similar way to how the closely related compound mitragynine is metabolised to the more active 7-hydroxymitragynine.
Akuammine is the main alkaloid found in the seeds, comprising 0.56% of the dried powder, indicating that the 250 mg "Picap Capsules" sold commercially should contain approximately 1.4 mg of akuammine, plus 0.085 mg akuammidine and 0.015 mg ψ-akuammigine. Akuammine is structurally related to both yohimbine and mitragynine, both of which are alkaloid plant products with uses in medicine.
Kratom, Akuamma and Sore-mouth Bush have been used as pain-killers in folk medicine practice. Their active principles have been discovered in modern pharmacological and chemistry studies.
The three pain killers and their extract preparations can be purchased online.
Kratom (Mitragyna speciosa) is a tropical evergreen tree and native to Southeast Asia (Indochina, Malesia):
Kratom leaves have psychoactive and are chewed to uplift mood and treat pain and so on health problems.
Kratom leaves have anti-inflammatory and antinociceptive effects.
Kratom leaves contain alkaloids 7-hydroxymitragynine and mitragynine which act on various receptors in the brain; mainly on opioid receptors.
7-Hydroxymitragynine is an opioid agonistic pain killer, 30- and 17-fold higher than that of mitragynine and morphine, respectively.
Mitragynine also acts primarily on μ-opioid receptors.
Kratom does not appear to have significant adverse effects, and appears not to cause the hypoventilation typical of other opioids.
Side effects associated with chronic kratom use include loss of appetite and weight loss, constipation, and darkening of the skin color of the face.
Chronic use has been associated with bowel obstruction.
Chronic users have also reported withdrawal symptoms including irritability, runny nose and diarrhea. Withdrawal is generally short-lived and mild.
Kratom is a controlled substance in Thailand, Bhutan, Australia, Finland, Denmark, Poland, Lithuania, Malaysia and Myanmar. It is not regulated in US.
Akuamma (Picralima nitida) is a tree and native to West Africa.
Akuamma seeds are used as folk medicine throughout West Africa.
Akuamma seeds are crushed or powdered and taken orally, and are mainly used for the treatment of malaria and diarrhea, also as a painkiller.
Akuamma has opioid analgesic activity.
Five alkaloids (akuammidine, akuammine, akuammicine, akuammigine and pseudo-akuammigine) were isolated from the seeds of Akuamma.
Akuammidine showed a preference for mu-opioid binding sites with Ki values of 0.6, 2.4 and 8.6 microM at mu-, delta- and kappa-opioid binding sites, respectively.
Pseudo-akuammigine exhibits anti-inflammatory and analgesic actions.
Their analgesic actions are mediated via interaction with opioid receptors.
Sore-mouth Bush (Psychotria poeppigiana) is a large shrub and native to tropical Americas, from Chiapas, Oaxaca, Tabasco and Veracruz in Mexico to the very north of Argentina. It does not occur on the Pacific side of the American cordillera.
Sore-mouth Bush contains Hodgkinsine, also contains trace amount of dimethyltryptamine.
Sore-mouth Bush is widely used as a painkiller.
Sore-mouth Bush decoction is used to treat headaches, sprains, rheumatism, muscular pains and bruises.
Pyrrolidinoindoline alkaloids identified in Sore-mouth Bush were reported having analgesic activity.
Hodgkinsine in Psychotria plants has antiviral, antibacterial and antifungal effects, but has mainly been researched for its analgesic effect.